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Out Of This World is an American fantasy sitcom about a teenage girl who is half alien, which gives her unique supernatural powers. It first aired in syndication from September 17, 1987 and ended on May 25, 1991. During its first season, the series was originally part of NBC's Prime Time Begins at 7:30 campaign, in which the network's owned-and-operated stations would run first-run sitcoms in the 7:30-8 pm time slot to counterprogram competing stations' game shows, sitcom reruns and other offerings. Out of This World was rotated with the original series Marblehead Manor and She's the Sheriff, a syndicated revival of the 1983 sitcom We Got It Made, and a television adaptation of the play You Can't Take It With You. NBC ended the experiment after the 1987-88 season due to the low ratings put up by three of the series, with Out of This World being one of the two that was renewed. After its first season the series was largely moved to weekend time slots, where it remained until its cancellation following the fourth season.

An honest marshal in a corrupt mining colony on Io, Jupiter's sunless third moon, is determined to confront a violent drug ring even though it may cost him his life. After his wife angrily deserts him, he waits alone for the arrival of killers hired by the company to eliminate him.

Damiel is now married to Marion, runs the pizzeria “Da Angelo” and the two have a child. The solitarily remaining angel Cassiel is more and more dissatisfied with his destiny as a mere observer of human life and finally decides to take the great leap. As Karl Engel he soon gets into a dubious milieu and finds himself as the assistant of the German American Baker, who makes his money with shady arms deals and sends films east in exchange for weapons. Cassiel’s adventure turns into a “thriller” when he decides to put a stop to Baker’s game.

In 1950s Connecticut, a housewife's life is upended by a marital crisis and mounting racial tensions in society.